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After participants have completed this survey we will send participants a link to the second survey, about dietary intake (completed on Because there is a designated window of time during which surveys must be completed, participants may receive a gentle reminder from us if time is running out. Participants are encouraged to consult with any providers you wish. Meissner WG, Frasier M, Gasser T, Goetz CG, Lozano A, Piccini P, Obeso JA, Rascol O, Schapira A, Voon V, Weiner DM, Tison F, Bezard E. Systematic review of levodopa dose equivalency reporting in Parkinson's disease. Objective: To test the effectiveness and long term safety of cannabinoids in multiple sclerosis (MS), in a follow up to the main Cannabinoids in Multiple Sclerosis (CAMS) study.Listing a study does not mean it has been evaluated by the U. We are attempting to identify practices, beliefs, and therapies used by individuals who report excellent quality of life, few PD symptoms, and reduced rates of progression.After agreeing to participate, we will ask participants to fill our questionnaires about their experience with PD, their health in general, along with their food intake every six months for five years.

Listing a study does not mean it has been evaluated by the U. Participants will be asked to complete online surveys every six months for five years.The time requirement is about an hour to an hour and a half every six months. Results: Intention to treat analysis of data from the 80% of patients followed up for 12 months showed evidence of a small treatment effect on muscle spasticity as measured by change in Ashworth score from baseline to 12 months (Δ-THC mean reduction 1·82 (n = 154, 95% confidence interval (CI) 0.53 to 3.12), cannabis extract 0.10 (n = 172, 95% CI −0.99 to 1.19), placebo −0.23 (n = 176, 95% CI −1.41 to 0.94); p = 0.04 unadjusted for ambulatory status and centre, p = 0.01 adjusted).

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There was suggestive evidence for treatment effects of Δ-THC on some aspects of disability. Overall, patients felt that these drugs were helpful in treating their disease.

Patients aged 18–64 years with clinically definite or laboratory supported MS, stable disease for the previous 6 months (in the opinion of the treating physician, rather than as measured by EDSS) and problematic spasticity (Ashworth score of at least 2 in two or more muscle groups), were recruited across 33 UK neurology and rehabilitation centres (see end of paper) between December 2000 and October 2002.

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